Analytical ultracentrifugation (AUC) is the method of choice when characterizing mixtures in solution. Offering much higher resolution than DLS and size exclusion chromatography, AUC represents the gold standard for characterizing many different solution-based systems and colloids. AUC is most appropriate for particles in the nanoscale regime, which includes all proteins, nucleic acids, carbohydrates, lipids, membrane vesicles, as well as inorganic and synthetic materials such as quantum dots, metal nanoparticles, carbon nanotubes and industrial materials like flocculants.

The experimentalist can modulate the sedimentation force by varying the speed, and modulate the sedimenting speed by adjusting density and viscosity of the solution and thereby cover a wide range of molecules with variable size, shape, molecular weight, density, and composition.

Application examples include: